Plasma proteomics in early cognitive decline

Name: Plasma proteomics in early cognitive decline
Published: 2026-09-29
License: Free for academics; commercial licence and real-run credits

Plasma protein panels and cognitive tests over three years.

AuthorsJamie Lee and R. Okafor

Versionv1 · Sep 29, 2026

LicenceFree for academics; commercial licence and real-run credits

Files4 files

Datasets4

visitsSPHERE1,180 × 18

age	sex	apoe4_group	education_y	visit_no	years_from_baseline	diagnosis	moca	mmse	cdr_sb	faq	gds	logical_memory	animal_fluency	bmi	sbp	diabetes	converted_2y
60	F	none	15	3	2	MCI	22	24	3.4	6	4	13	20	32.0	127	0	1
82	F	none	15	3	2	CN	27	29	0.5	0	3	17	20	27.8	141	0	0
75	F	none	11	4	3	MCI	22	24	2.9	8	0	12	10	28.9	128	0	1
64	F	two	12	3	2	CN	28	30	0.7	2	0	18	9	21.9	113	0	0
72	M	one	17	3	2	CN	29	30	1.0	5	1	20	20	32.0	120	0	0
76	F	two	16	4	3	MCI	22	24	1.2	6	7	0	23	20.7	133	0	1
86	F	none	19	4	3	MCI	21	23	3.7	4	1	17	18	25.4	122	0	1
87	F	two	19	4	3	CN	27	29	1.0	6	2	15	12	24.7	119	1	0
66	F	none	17	1	0	CN	27	29	0.2	0	2	3	22	25.0	126	0	0
74	M	one	10	1	0	MCI	25	27	1.7	0	0	16	15	28.9	152	1	0
77	F	one	14	3	2	AD	20	22	5.3	11	3	10	23	23.8	110	0	0
65	M	none	10	4	3	CN	27	29	0.4	2	0	9	22	32.8	118	0	0
81	M	none	16	2	1	MCI	23	25	1.1	7	3	15	19	29.7	129	0	0
82	M	none	17	3	2	AD	20	22	9.5	9	6	24	12	27.5	113	0	0
87	F	two	18	4	3	CN	29	30	0.6	9	5	4	22	32.4	153	0	0
80	F	none	11	1	0	CN	29	30	0.9	4	8	0	15	23.3	118	0	0
63	F	one	17	3	2	CN	27	29	0.9	3	0	23	17	22.9	149	0	0
63	F	two	18	3	2	MCI	24	26	3.8	4	8	11	13	23.9	135	0	0
61	M	none	16	2	1	CN	29	30	0.1	6	4	7	15	30.1	145	0	0
87	F	one	18	4	3	CN	26	28	0.2	3	2	11	24	29.5	152	0	0

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