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Plasma p-tau217, GFAP and NfL · Stanford ADRC

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plasma-biomarkersSPHERE612 × 10

participant_id	age	sex	diagnosis	apoe4	ptau217_pg_ml	gfap_pg_ml	nfl_pg_ml	ab42_40_ratio	amyloid_status
ADRC-1000	60.8	M	HC	1	0.238	55.4	11.6	0.0641	positive
ADRC-1001	82.2	F	MCI	0	0.132	98.6	25.5	0.0707	negative
ADRC-1002	66.2	M	AD	1	0.661	89.9	25.4	0.0598	positive
ADRC-1003	58.7	M	HC	0	0.621	71.8	9.7	0.0618	positive
ADRC-1004	71.9	F	DLB	0	0.57	121.5	27.6	0.059	positive
ADRC-1005	65.5	M	PD	1	0.266	43.6	6.7	0.0672	negative
ADRC-1006	63.8	M	HC	2	0.134	23.9	8.1	0.076	negative
ADRC-1007	85.7	F	MCI	1	0.875	138.3	23.6	0.0601	positive
ADRC-1008	69.3	F	PD-MCI	0	0.138	81.8	12.7	0.0712	negative
ADRC-1009	82.7	M	HC	0	0.764	120.9	24.9	0.0624	positive
ADRC-1010	68	F	PD	1	0.246	62	13	0.0684	negative
ADRC-1011	72.2	M	HC	0	0.331	92.2	18.6	0.0759	negative
ADRC-1012	74.3	M	HC	0	0.24	76	15	0.0631	negative
ADRC-1013	64	F	MCI	0	0.418	111.6	8.2	0.0557	positive
ADRC-1014	84	F	PD-MCI	1	0.206	115.2	32.5	0.07	negative
ADRC-1015	72.7	F	HC	0	0.124	93.3	10.1	0.0741	negative
ADRC-1016	79.8	M	DLB	0	0.331	99.8	28.7	0.0622	negative
ADRC-1017	67.2	F	HC	0	0.463	91.3	7.8	0.0536	positive
ADRC-1018	63	F	HC	0	0.575	93.5	9.3	0.06	positive
ADRC-1019	77.3	F	HC	1	0.121	105.2	11.6	0.0756	negative

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README

Plasma biomarkers at baseline

The Biomarker Core measured four blood-based markers of Alzheimer’s and related disease in 612 participants at their baseline visit. Plasma p-tau217 is the strongest single blood marker of amyloid pathology; GFAP reflects astrocyte activation; NfL reflects axonal injury across many neurodegenerative diseases.

What is in it

Column	Unit	Assay
`ptau217_pg_ml`	pg/mL	Lumipulse G p-tau217
`gfap_pg_ml`	pg/mL	Simoa GFAP Discovery
`nfl_pg_ml`	pg/mL	Simoa NF-light
`ab42_40_ratio`	ratio	Lumipulse Aβ42 and Aβ40
`amyloid_status`	positive / negative	PET or CSF, within 12 months

How to use it

library(sphere)
bm <- sphere_load("stanford-adrc/plasma-biomarkers", dataset = "plasma-biomarkers")
aggregate(ptau217_pg_ml ~ diagnosis, data = bm, FUN = median)

Values below the assay’s lower limit of quantification are set to that limit. See docs/assay_protocol.pdf for the limits and the plate controls.

Cite

Mensah K, Oyelaran M, et al. Plasma p-tau217, GFAP and NfL in the Stanford ADRC cohort. Stanford ADRC, 2026. Funded by NIH/NIA grant P30AG066515.